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Type 2 diabetes prevented in 80 per cent of at-risk patients thanks to repurposed drug Date: February 23, 2017

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Prediabetes progresses into diabetes in 5-10 per cent of sufferers inside ten years, say researchers. Credit score: © Sherry Younger / Fotolia A weight reduction drug has diminished the chance of kind 2 diabetes by 80 per cent in comparison with placebo. The drug, which will increase the quantity of appetite-supressing hormones produced by the intestine, was examined on obese individuals with 'prediabetes'. That is also referred to as 'borderline diabetes,' and is characterised by barely elevated blood sugar ranges. The situation usually results in kind 2 diabetes when untreated. Prediabetes impacts one in ten individuals within the UK, and progresses into diabetes in 5-10 per cent of sufferers inside ten years. Prediabetes is curable with train and a more healthy weight-reduction plan, however as soon as it progresses into diabetes, it's considerably tougher to deal with. Each situations are stron...

Gastric balloon is new weight loss option

The Orbera® gastric balloon is made of soft silicone. It is inserted through the mouth and esophagus and then filled with saline solution (salt water). The patient feels full on smaller portions of food. The balloon is kept in the stomach for six months, during which time the patient adapts to eating healthier portion sizes. Patients who receive the gastric balloon plus medical weight loss therapy lose more weight than patients who undergo medical therapy alone, said Bipan Chand, MD, director of the Loyola Center for Metabolic Surgery and Bariatric Care. The balloon is less invasive and has fewer risks than gastric bypass and other bariatric surgeries, but the weight loss is less dramatic, Dr. Chand said. Dr. Chand said the gastric balloon generally is indicated for patients with a body mass index (BMI) between 30 and 40. ( BMI is a measure of body fat based on height and weight. A BMI higher than 25 is overweight, and a BMI higher than 30 is obese.) Patients who undergo medica...

The role of weight in postmenopausal women's longevity

Interestingly, Hispanic women in the study had a lower mortality rate at any given body mass index or waist circumference compared with non-Hispanic whites or African-Americans. "We have used data from the large prospective cohort of the US Women's Health Initiative to add evidence on the relationship of general and central obesity with all-cause mortality in older women, especially in African American and Hispanic American older women, who have not been well represented in previous research on this topic," said Dr. Zhao Chen, lead author of the  Journal of the American Geriatrics Society  study. "Our study findings have called public health attention to reduce central obesity in older women from different racial /ethnic groups and to reconsider recommendations on the range of healthy body mass index in older women." for more information visit our product website:  Buy Vidalista 60 mg Online 

Science Newsfrom research organizations Early birds may make healthier food choices than night owls

"Early birds may have an extra advantage over night owls when it comes to fighting obesity as they are instinctively choosing to eat healthier foods earlier in the day," said TOS spokesperson Courtney Peterson, PhD, of the University of Alabama at Birmingham. "Previous studies have shown that eating earlier in the day may help with weight loss and lower the risk of developing diabetes and heart disease. What this new study shows is that our biological clocks not only affect our metabolism but also what we choose to eat." Researchers looked at data from nearly 2,000 randomly chosen people to determine if their circadian or biological clock rhythm (chronotype) affected what they ate and at what time. Clear differences in both energy and macronutrients between the two chronotypes abound, with morning people making healthier choices throughout the day. Evening types ate less protein overall and ate more sucrose, a type of sugar, in the morning. In the evening, they...

Effects of a poor diet during pregnancy may be reversed in female adolescent offspring

"These are provocative findings," said Thoru Pederson, Ph.D., Editor-in-Chief of  The FASEB Journal ." So many effects during pregnancy have been touted as irreversible -- perhaps not always so. " In their study Reyes and colleagues used four groups of female mice. The first group was fed a control diet during pregnancy and lactation. The second group was fed a high-fat diet during pregnancy and lactation. The third was also fed a nutrient-enriched diet during early life. The fourth group included offspring from the mice fed a high-fat diet that were fed the nutrient -enriched diet during early life. When all mice were adults, they were fed the same control diet for the remainder of their lives. Researchers then used operant behavior chambers (chambers in which a mouse must nose-poke into a hole to get a reward) to examine learning and motivation. They found that the female offspring who were fed the nutrient-enriched diet during early life learned faster and w...

Ketogenic diet shown safe, effective option for some with rare and severest form of epilepsy

In a report on the trials, published online Feb. 8 in  Neurology , the investigators conclude that the diet is a "feasible" option for people with so-called super-refractory status epilepticus (SRSE), the most severe seizure classification, in which up to an estimated 60 percent of patients die once they develop this type of seizure. According to the Centers for Disease Control and Prevention, more than 5 million people in the U.S. have a seizure disorder. More than 150,000 people in the U.S. each year will develop refractory status epilepticus and, according to published studies, about half of those will develop super-refractory seizures. "From our past research, we know the ketogenic diet is effective in approximately one-third of adults with epilepsy who are resistant to traditional anti-seizure drugs," says Mackenzie C. Cervenka, M.D., associate professor of neurology and director of the Adult Epilepsy Diet Center at the Johns Hopkins University School of...

Could a ketogenic diet alleviate gout?

Recent work from the laboratory of Vishwa Deep Dixit, Professor of Comparative Medicine and Immunobiology, has shown that the ketone body β-hydroxybutyrate can specifically inhibit the NLRP3 inflammasome. Ketones are byproducts of fat break down in the liver that can serve as alternative metabolic fuels for the brain and heart during periods of low carbohydrate intake, such as fasting, or ketogenic diet. To test if elevating ketones protected against inflammation during gout, a Postdoctoral Fellow in Dixit's lab, Emily Goldberg, and Associate Research Scientist and Clinical Veterinarian in Comparative Medicine, Jennifer Asher, and their colleagues collaborated to develop a novel model of gout flares in rats. They found that feeding rats a high-fat, low-carbohydrate ketogenic diet increased β-hydroxybutyrate levels and protected rats from joint swelling, tissue damage, and systemic inflammation normally seen during gout. "In isolated neutrophils , β-hydroxybutyrate comp...